After a review of postmarketing adverse event reports, FDA determined that an updated label with a boxed warning on the risks of heart failure and other Avandia Side Effects were needed for the entire thiazolidinedione class of antidiabetic drugs.

These drugs are used in conjunction with diet and exercise to improve blood sugar control in adults with type 2 (non-insulin-dependent) diabetes. Manufacturers of certain drugs have agreed to the upgraded warning. Food and Drug Administration officials are pushing for a “black box” warning on GlaxoSmithKline Plc’s hard-hit diabetes drug Avandia, the Wall Street Journal reported, citing sources.